SUMMARY OF THE STUDY The surgeon recommended complete removal of my thyroid. I'm looking for any and all help and/information you can share with me. Repeat Fine Needle Aspiration Cytology Refines the Selection of Thyroid Nodules for Afirma Gene Expression Classifier Testing. In this study from Boston, 63 thyroid surgical specimens were reviewed from patients whose thyroid biopsy samples were read as indeterminate and in whom the GEC test was reported as suspicious. But, I'm also tired of living with the uncertainty and semi-annual nerve sessions after each ultrasound. something nodule with a majority of Hurthle cells with normal thyroid blood tests and the Afirma test came back 40% suspicious,it grew even bigger in two years and was hypoechoic and vascular on the ultrasound like mine and she said this concerned her and the radiologist,she said (she said my nodule sounds a lot like hers except hers was bigger) so she had half her thyroid out and this nodule was benign! The aggressive one wants to cover his ass in the tiny chance you have an aggressive thyroid cancer, and the wait and see one is playing the odds that there is nothing to worry about, and that unneeded surgery has risks that are higher than the benefits in your case. If benign = no surgery, IF suspicious or malignant = surgery. One such test is the Afirma gene test. the nodule was only 1.5 cm and I really had no concerning symptoms. On this topic from this forum member bmcm2girls said she too had a false suspicious result from the Afirma test and her nodule was benign when removed. BACKGROUND Afirma BRAF V600E o Afirma BRAF testing may be considered for either GSC or FNA suspicious or malignant results. While most thyroid nodules are non-cancerous (Benign), ~5% are cancerous. suspicious - ~50% risk of cancer. I didn't take the nodule too seriously, but did see a specialist and also got the FNA. It is illegal for auto mechanics to do work on our car without an estimate, or accountants, lawyers etc but doctors and medical facilities can just run us into BK without any regard. He recently emailed me back and said,as we discusssed on the phone,he agrees with many of my concerns about the Afirma test. And she's just mostly silent about it. The benign call rate for GSC was 76.2%. This study suggests that more research is needed to determine if the noninvasive follicular variant thyroid cancer can be diagnosed by molecular markers without proceeding to surgery. Is is the Benign that is a false negative ? 2021 Apr;10(2):168-173. doi: 10.1159/000509037. o The Afirma MTC testing must be billed as part of the Afirma GSC. B. My surgeon and endocrinologist said no further treatment is needed but to continue observation. I've read a lot about this test (both good and bad). No it's actually the opposite.Many studies by different endocrinologists that were published in The American Thyroid Association's Journal in 2012 found that only 4% of the time the Afirma test falsely says cancerous nodules are benign but it falsely calls benign nodules ''suspicious'' at least 48% of the time! Method: The range of confirmed cancer (post surgery) from different studies was as low as 17% to as high as close to 50%. I've been battling hypothyroidism and suspicious thyroid nodules for 4 years. So I gather if I am reading what you reported correctly, your case is another false NEGATIVE for the Afirma test? The doc mentioned the thyroid and upon a physical exam felt the nodule, leading to the rest of the testing. BTW, I'm about to turn 50 and I have no thyroid issues other than this. So, if you were going to go down that route then this will save you from having a second biopsy. Afirma BRAF V600E o Afirma BRAF testing may be considered for either GSC or FNA suspicious or malignant results. 2021 Aug;31(8):1253-1263. doi: 10.1089/thy.2020.0969. I was told that my thyroid needs to be removed (at least half, possibly all). This did not surprise me since I had researched "suspicious." Now having dodged a few close bullets, I was like wobble head to my new endo's treatment plan which included 100 mci RAI though after reading my path report that I may be at little higher risk with "variant" than most others. Still, I can see my nodule on one side and don't want to risk having cancer in my body, so I was ready to set up the surgery as soon as possible. result (eg, benign or suspicious) Public Comment. One of the hardest things about all of this is the adjustment. 2017;45:308-311. I pointed out to them that since the nodule tested was less than 1cm the radiologist should not have sent it and they should not have tested it. Molecular Markers: genes and microRNAs that are expressed in benign or cancerous cells. I'm a 39 years old male. On cytologic evaluation 3.0% of the cases were non diagnostic (ND), 9% benign, 62% AUS, and 26% suspicious for neoplasm (SN). PMC The doctor uses a very thin needle to withdraw cells from the thyroid nodule. With each step, I'd expected to hear, "yeah, you are a lumpy person, but no cancer." microRNA: a short RNA molecule that has specific actions within a cell to affect the expression of certain genes. The rate of malignancy in nodules suspicious for neoplasm (SN) on cytology interpretation was 31.2% (5/16). Silaghi CA, Lozovanu V, Georgescu CE, Georgescu RD, Susman S, Nsui BA, Dobrean A, Silaghi H. Front Endocrinol (Lausanne). Thyroid cancer support group and discussion community. Thyroid nodule biopsies are used to identify if a nodule is cancerous or determine the risk that a thyroid nodule may be cancerous. I'd done enough research to know that Thyroid cancer is generally treatable, and was sure to tell them about that. Patient medical records were retrospectively reviewed for clinical history, FNA results, radiologic findings, management and follow-up. In such cases, testing of molecular markers related to thyroid cancer may help determine the risk of cancer. I had numerous FNA biospy's last result "suspicious for follicular neoplasm " , the last ultrasound showed several microcalcifications on left and scattered microcalcification on the right. After hearing this, I felt a huge kick in my gut and also stupid for getting a second opinion for a fine needle biopsy though I'd ended up with an endo, who wrote articles on the subject. The authors concluded that a GEC suspicious test result may include noninvasive follicular variant papillary thyroid cancer as well as classical papillary thyroid cancer. Everyone's story and experience seemed to be totally different. I do not have calcifications but all 4 nodules are solid, hypoechoic and vascular. Thyroid. BACKGROUND The rate of malignancy in nodules suspicious by Afirma was 18.3% (11/60). Don't want to gain weight or feel less optimal then I am now. Baca SC, Wong KS, Strickland KC, Heller HT, Kim MI, Barletta JA, Cibas ES, Krane JF, Marqusee E, Angell TE. Thyroid bloodwork normal. Sorry for such a long post, but as Im sure you remember, those first few days after receiving this type of news, Im full of questions and anxiety. I find out my biopsy results next week. Now can anyone shed some light on any negative effects of RAI on your body in the long-run? So when I say the doctor's says suspicious for cancer with a 75% possibility, I'm not sure how she gets 'unlikely' from that. Well, this last spring my endo said she didn't like my latest ultrasound results. Anyone have AUS nodule with suspicious Afirma results end up cancerous? So much good info but I wish I had read this before I had agreed with my endo on his prescription for rai:( In fact, i am currently on my fifth day of my 7-10 day rai staycation. First off, I understand about 25% of suspicious actually turn out to be cancer (not that I should just "roll the dice") Thyroid nodule: an abnormal growth of thyroid cells that forms a lump within the thyroid. Afirma GSC is a pre-operative genomic test for thyroid tumor biopsies that have . Will find out results in about a week. That didn't sit well with me. My AFIRMA is also 40% risk. http://biotechstrategyblog.com/2012/06/veracyte- afirma-gene-expression-classifier-thyroid-cancer- diagnostic-test.html/ I'm sure that over the years as more people have this Afirma test done,there will be even more people posting on thyroid and general health boards about getting false "suspicious" results from it! At the end of his great article in the journal Clinical Thyroidology August 2012 criticizing the inaccuracies and unreliabilities of the Afirma test, endocrinologist of 50 years Dr.Jerome Hershman says, Currently the Veracyte Affirma GEC method "retails" for 3,350 plus 300 for cytopathology. 2. The .gov means its official. Bethesda, MD 20894, Web Policies A month ago I had the Afirma test and it came back positive - suspicious for cancer which increased my chance from 5% to 50%. So the probabilities of malignancy for the various Bethesda risk categories are going to change. A publication of the American Thyroid Association, Suspicious readings of the Afirma gene-expression classifier include some noninvasive encapsulated follicular variant of papillary thyroid carcinomas. Thyroid 2016;26:911-5. Afirma testing is back "Risk of malignancy: Afirma GSC Suspicious ~50%" "Malignancy classifiers: Negative" "MTC and BRAF classifier results were negative and RET/PTC1 and RET/PTC3 were not detected. benign), 25% of cases had follicular variant papillary thyroid cancer, 2% of cases had classical papillary thyroid cancer and 8% of cases had follicular thyroid cancer. Partially Encapsulated Follicular Variant of Papillary Carcinoma. Polavarapu P, Fingeret A, Yuil-Valdes A, Olson D, Patel A, Shivaswamy V, Matthias TD, Goldner W. J Endocr Soc. Noninvasive follicular variant of papillary thyroid carcinoma and the Afirma gene-expression classifier. Have lots of decisions to make and just trying to do some homework. Among the 25 papers that approached Afirma GEC, four studies enrolled an additional number of 635 TNs from 596 patients to evaluate the Afirma GSC (16, 17, 57, 70). The Afirma gene sequencing classifier (GSC) performs better in indeterminate thyroid nodules than the Afirma gene expression classifier (GEC). I am hesitant to go to surgery with the 30% cancer chance without more information. The biopsy (Afirma) was indeterminate with GSC suspicious with a 50% ROM. There are risks and benefits to any decision - and humans are very bad at assessing both. Because of this rather benign course, some pathologists have even questioned whether this subgroup is a cancer after all. See Somatic Mutation Testing - Solid Tumors guideline for criteria. https://www.inspire.com/groups/thyca-thyroid-cancer-survivors-association/discussion/genetic-test-two-different-results/reply/6888430/?msg_activity=reply_posted. Until now, Afirma has been available as two tests: Afirma GSC and Afirma Xpression Atlas (XA). I've swallowed the I-131 pill, what are negative effects in the long run? It took about 8 days to get back results. False Positives. Thanks. 2020 May;162(5):634-640. doi: 10.1177/0194599820911718. A thyroid nodule biopsy can be benign (normal), malignant (cancer) or indeterminate. See Somatic Mutation Testing - Solid Tumors guideline for criteria. Papillary thyroid cancer is the most common type of thyroid cancer. This was done in hopes of maintaining my own thryoid function which the doctors and I felt better than taking thyroid medicine daily for the rest of my life. I am still holding off on surgery for now. For one thing, I had some pain on one side after biopsy. If all nonsurgical GEC benign cases were actually benign, when evaluating the cases that had surgery, the chance that a GEC suspicious nodule was actually cancer was 33.3% and the chance that a GEC benign nodule was actually benign at surgery was 98.2%. Noninvasive Follicular Variant of Papillary Thyroid Carcinoma and the Afirma Gene-Expression Classifier. http://www.thyroidboards.com/showthread.php? Current analysis of thyroid biopsy results cannot differentiate between follicular or hurthle cell cancer from noncancerous adenomas. I just wrote that these are 25% of all thycas, but I have read just recently that the figure might be anywhere between 15-25% because there are varying standards for diagnosing these between different institutions. I am scheduled to have a TT on March 9th and I wish I felt a little better about my decision. 2020 Sep;8(9):e1288. I had three biopsies on a completely solid 2.0cm nodule, all which came back indeterminate/AUS. I almost want to cancel the surgery. I am wondering if anybody can comment on whether my case described below is considered to be reclassified according to the recently released guidelines. SUMMARY OF THE STUDY Mol Genet Genomic Med. I am not afraid of the surgery, only would really be disapointed if a vital organ was removed from my body for nothing. On surgical resection 82% were benign, with 45% follicular adenoma (FA), and 37% nodular goiter (NG). I wasn't one to resist. I have also read a recent 2015 report that posits that there are built-in subjectivities to begin with at the Ultrasound/Pathology level yielding "Indeterminate" or "Atypical Cells" to begin with that then sets up a natural path to getting a "Suspicious" result from Afirma. A 36% Increase in Specificity With Afirma GSC Versus Older Test . t=5283], http://www.thyroidboards.com/showthread.php? More than one doctor has told me I should just have surgery, at least half the thyroid, maybe the whole thing. It mentions possible microcalcification, which has never come up before. eCollection 2021. I had another biopsy which came back showing "Atypical cells". Cancer Cytopathol. Results came back 50% Suspicious for FN(Follicular Neoplasm) with positive HRAS c.18HRAS c.182A>G (Q61R) Hello, new here and confused, anxious and a bit worried. It was .62cm by then. One > 4cm, but has tested benign by FNA 4 times Indeterminate thyroid nodules in the era of molecular genomics. Unable to load your collection due to an error, Unable to load your delegates due to an error. The Afirma gene sequencing classifier (GSC) performs better in indeterminate thyroid nodules than the Afirma gene expression classifier (GEC) BACKGROUND Thyroid nodules are very common, occurring in up to 50% of individuals. Afirma was suspicious. Endo M et al 2019 Afirma Gene Sequencing Classifier compared with Gene Expression Classifier in indeterminate thyroid nodules. Neither will talk to the other. Another problem with Afirma is that pretty soon they are going to have to adjust the test to the reclassification of non-invasive FVPTC. THE FULL ARTICLE TITLE Genes: a molecular unit of heredity of a living organism. Then in December 2014 I thought to have it checked again, with the same results although this time I had it send for the Afirma testing which I was told is more accurate test for cancer. Genes hold the information to build and maintain an organisms cells and pass genetic traits to offspring. I'm shocked that my voice is still completely in tact. That not only had the nodule continued to grow (from 2.0 to 3.2cm over the last 2 years), but it is now showing increased central vascularity. Epub 2020 May 21. The moment that I've been so nervous about finally came yesterday. There are four types of FVPTV: encapsulated with invasion, encapsulated without invasion, unencapsulated non-invasive and unencapsulated and invasive into the surrounding parenchyma of the gland. I've read a lot about this test (both good and bad). Can someone give me their take on my fna results? Conclusion: I can learn to live healthier, and to appreciate each day, and to love and support more readily. I have made an appointment with another endocrinologist, but just to talk to him. But, I am concerned about the report I just received. 2016 Wiley Periodicals, Inc. Keywords: I welcome your thoughts on my case. Mild lymphocytic thyroiditis ( nonspecific) My expensive, unsolicited, Afirma test results came back as negativegood thing I had already had my TT before I received the results; I have stage III pap/follicular thyca. Clinician should therefore exercise caution in using this result for treatment decisions. Can you expand on this? However, the interesting twist was that cancer was not detected on the nodules being monitored, there was a little sucker hidden behind all these years according to my surgeon and this was why the pathologist at my local hosp could not come up with definitive conclusion as he/she was only focused on the biopsied nodules:( Here's what a friend of mine wrote who is a retired neurologist: "They can both be right for different reasons, or from different perspectives. Second, this nodule has been stable and has not grown from the first day it was discovered. My Enfo bumped up my Synthroid right away to adjust for the surgery. 4,6 In addition to the benign versus malignant classifier, the Afirma GSC suite includes That was a hard Thanksgiving. 5. Any help really will be appreciated. -Male - Slightly Hypothyroid which began over the past year or so One such molecular marker test is the Afirma gene expression classifier (GEC) test. A total of 27 patients with GEC benign nodules had surgery for nodule growth or patient preference and 3 had a papillary thyroid microcarcinoma discovered at final pathology while the rest were benign. I have bumps on my head that come and go and are considered normal, and another cyst on my arm that I've had since I was eleven -- also normal. -No Size changes of Nodule in last 2-3 months (duration of time to get all of these tests) Surgical margins: negative for tumor (tumor is < 0.1cm from margin) Otolaryngol Head Neck Surg. It seems like with every ultrasound, some new suspicious characteristic pops up. Cancer Cytopathol. Nevertheless, I am reluctant to just proceed particularly for the following reasons: Arma XA is not performed on GSC Benign nodules.7 IIIIV Atypia of Undetermined Signicance This occurs in 1520% of biopsies and often results in the need for surgery to remove the nodule. Thyroid nodules are commonly found on ultrasound of the neck and the evaluation of a thyroid nodule may include thyroid biopsy. They did not address that issue in their letter, just my income. Home Patients Portal Clinical Thyroidology for the Public October 2016 Vol 9 Issue 10 p.11-12, CLINICAL THYROIDOLOGY FOR THE PUBLIC I did not get to go under the knife for my TT til this past March. -38yrs old Thyroid nodule: an abnormal growth of thyroid cells that forms a lump within the thyroid. I understand that Afirma tends to have a lot of false positives, but it's supposed to be fairly accurate for negative results. When the nurse called she couldn't even tell me results over he phone -- she said she didn't know them -- but set up an appointment for end of the following week -- another wait. This large study demonstrates that almost one-half of Bethesda III/IV Afirma GSC suspicious and most Bethesda V/VI nodules had at least 1 genomic variant or fusion identified, which may optimize personalized treatment decisions. Recently I change insurance and in doing so, my new doctor ordered a ultrasound which showed the nodule and he felt it was nothing to worry about. Therefore, a new version of the Afirma test was created called a gene sequencing classifier (GSC) to better predict thyroid cancers in indeterminate nodule while still being able to rule out cancer in benign nodules. I'm a foodie who has always struggled with weight, but I also exercise so I'm always just plump but in otherwise decent health. In early September, at a well-woman visit, my primary care doctor found a lump in my neck and sent me for a sonogram that found three nodules -- one estimated at 3.5 cm, one at 1.5 cm and the third much smaller. So the jump from that mentality to that of, "oh, I can get cancer, too" has big a huge one for me. If you have benign results they always wonder. The GSC correctly identified 41 of 45 malignant samples as suspicious, yielding a sensitivity of 91.1%, and 99 of 145 . Living beings depend on genes, as they code for all proteins and RNA chains that have functions in a cell. Hello. Follicular Neoplasm. The surgeon was great. The positive predictive value of the GSC is 47.1%.1 Results Afirma GSC results may help guide surgical decision making in patients with thyroid nodules. Genes: a molecular unit of heredity of a living organism. :-). It is unclear whether mutations in these genes cause the cancer or are just associated with the cancer cells. Variant: Afirma XA: Informs selection of surgical and therapeutic decisions for Afirma GSC Suspicious, Bethesda V, and Bethesda VI nodules 1 Is clinically validated 1 and informed by The Cancer Genome Atlas (TCGA), 2 extensive published literature, and Veracyte R&D discovery using nearly 40,000 samples 3 Follicular and hurthle cells are normal cells found in the thyroid. This site needs JavaScript to work properly. These 3 papers report the performance of these assays in evaluating Bethesda III and IV indeterminate biopsies. No parathyroid tissue identified. However, its relatively low positive predictive value (PPV) limited its use as a classifier for patients with suspicious results. Among the 22 with only a TP53 alteration, the first 16 consecutive nodules were included (7 nodules were Bethesda III and 9 nodules were Bethesda IV). Afirma said NEGATIVE for BRAF and Meduliary but still assigned a classification of "Suspicious" with 40% chance of cancer. Once you go down the hole, there are no good statistics to guide you in making rational decisions in an irrational area of medicine - AND as you know, no decisions in medicine in even cut and dried cases are so simple as to have no opposing point of view. The mindset of most surgeons is to cut it out - ignoring the risks of that approach. A woman on the excellent health site Medhelp told me she had a 3cm. (Afirma GSC suspicious, suspicious for malignancy, or malignant cytopathology) ,2,4,8 Thyroid. Well her Afirma test result was benign,but not long after she had her thyroid removed and found she had papillary cancer that had spread into her central lymph node and she said that her surgeon told her that the Afirma test is not very reliable! Thoughts or experiences?? I didn't make a big deal about the cost because I am having surgery and they money I paid was my 20% co-pay and my out of pocket limit is almost met. I have met with multiple surgeons, and am meeting with the one I am selecting on Friday and wanted some info on what to do, and how to proceed. Without my knowledge 4/5 of my FNA biopsies came out fine but 1/5 had "atypical" cells and they were sent to Afirma without my knowledge. These results do not change the risk of malignancy of the (ROM) of the Afirma GSC suspicious result." Dr.Jerome Hershman. Should I be treating this as a Hurthle Cell Lesion, or should I just relax. It just really annoys me that doctors can order tests that cost us money without our consent. The results of the GEC are either read as suspicious for cancer or benign. He said this Afirma test is wrong half the time misclassifying benign nodules as suspicious,(I'm sure it's even more than half!) I'm curious, if you had similar biopsy results and had surgery, was your final path malignant or not? My doctor then sent me to an endocrinologist for a biopsy which came back with atypical but inconclusive results. Choosing to have the surgery was the most difficult decision ever, since I wasn't sure if my nodule was cancerous or not, and of course I didn't want to go through the surgery all for nothing. 3. I was told the only way to find out for sure is to have half my thyroid removed. Anyone here have a false NEGATIVE Afirma GEC result? No one was telling me that. Largest is 2.3(previously 1.8cm in 2014) different test center though. I appreciate any and all responses, and please do respond, I need as much information as I can get and I live by the saying, "you don't know what you don't know." I immediately started crying, knowing that a phone call wasn't "the good news." Afirma Gene Expression Classifier: a test for a group of molecular markers in thyroid biopsy specimens in order to determine the likelihood that a thyroid nodule is benign or cancerous. Lastly I do 25mcg of levothyroxine once a day for Hypothyroidism, it was prescribed based on lab results, not on how I was feeling. I was informed in August of 2013 after a FNA that one of my nodules was suspicious and the recommendation was a TT. She admitted once she thinks cancer is unlikely. Used for FNA indeterminate nodules (bethesda III-IV). I'm fearful this is a Hurthle Cell Lesion, and I do not like what I have read. Genes hold the information to build and maintain an organisms cells and pass genetic traits to offspring. They billed my insurance $6684 - my ins negotiatied $3370.40 they have billed me for 883.71, I applied for a reduction but they say I make too much income so I am not eligible for one. 2017 May;125(5):313-322. doi: 10.1002/cncy.21827. He then says, However,another interpretation is that the method can be used only to classify a nodule as benign and the "suspicious" category by GEC should not be used. Multiple nodules. She didn't seem overly concerned based on all my previous records. Thank God I have good insurance but in the end my medical out of pocket for all of this could cost me up to $4,500. Epub 2021 Jun 22. -Afirma Test: "Suspicious for Malignancy" - NEGATIVE for BRAF, MTC, RET/PTC1 and RET/PTC3 The biopsy (Afirma) was indeterminate with GSC suspicious with a 50% ROM. Advice needed please. 2013 Dec;24(6):385-90. doi: 10.1111/cyt.12021. I regard this as a substantial cost for it's possible contribution to avoiding diagnostic surgery,in part because it also misclassifies lesions as suspicious about half the time. 1). A. The Afirma Genomic Sequencing Classifier (GSC) provides physicians with a comprehensive solution for a complex landscape in thyroid cancer diagnosis and individualization of care. My surgeon wants to operate right away stating that these kind of results have a 90% truancy for cancer to be present. Epub 2020 Mar 17. I have found this community very informative, thank you. I opted for a total after much thought because I had three un biopsied nodules on the other side and was already hypo with my entire thyroid to begin with. I was told to monitor my nodules every couple years using ultra-sound and if they increased in size, they needed to have FNA done. Of the 164 GSC nodules, 29 (17.6%) underwent thyroid surgery. Thyroseq v3, Afirma GSC, and microRNA Panels Versus Previous Molecular Tests in the Preoperative Diagnosis of Indeterminate Thyroid Nodules: A Systematic Review and Meta-Analysis. So, I found a new endo, whom I absolutely loved at my first appointment. I did not necessarily like that simplistic answer and I told him, you have nothing to compare it to, since he had not seen my past records. Afirma; FNA; cytology; thyroid nodules. I am very athletic , very healthy and happy ,don't want to give up any of that !!! I'm not against surgery if needed, but wondering shouldn't it be followed for a bit before such a drastic measure is taken. WHAT ARE THE IMPLICATIONS OF THIS STUDY? The Affirma Genomic Sequence Classifier (GSC) is based on DNA sequencing. Local surgical pathology diagnoses were available for 11 of these nodules. 4) How do I make sure I get the best care? Wong KS et al. and transmitted securely. For some reason, my long time best friend is one of the least supportive in all of this. So far, no problems with calcium. Only when I had a follow up visit with a cardiologist in JAn.of 2016 he noticed the results after requesting the previous scan results. 1. for my adopted daughter as she's already lost her bio-parents and thus my husband and I became her new parents.I've stayed like zombie while awaited my total neck ultrasound results and they came back CLEAR any cancer spreading to lymph nodes..yey! Like she was just trying to tie up loose ends, and I happened to be one of those loose ends. Long story short, after consulting a reputable endo with 25+ years of exp and hearing that I needed a total neck ultrasound to rule out any possible cancer spread to my lymph-nodes, I could not help but ask him if thyroid cancer is the slowest growing of all cancers and why the concern of cancer-spread only after year after diagnosis.here's the bomb I was not ready for or did not expect: my doc's said that he could not rule out the possibility this cancer may have started back in 2002 but remained to be such a small size of 1.4 cm for all these years. Results: Afirma result was suspicious in 69 cases. detect variants in greater than 50 genes. Accessibility 1) Cytologist did not classify this as a Hurthle Cell Lesion Is it a Hurthle Cell Lesion due to predominance of Hurthle Cells? Third, I have no history of thyroid cancer (or any cancer) in my family. Epub 2017 Feb 2. No lymphovascular invasion is identified. I have since found several more women who had false Afirma test results and had surgery and their nodules were also benign! I have 1.6 cm nodule on my right lobe.
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